Scientific background to Axomera therapy (Percutaneous Bioelectric Current Stimulation)


axomera brief description

The multi-patented Axomera therapy (percutaneous bioelectric current stimulation) is a new, transformational, microprocessor-controlled stimulation method that is increasingly used by orthopedists, sports physicians and pain therapists for the conservative treatment of acute and chronic disorders of the tendons, ligaments and muscles. It is based on the modulation of static, tissue-specific electric fields.

axomera is different from all other medical stimulation methods known to us

Until now, almost all medical electrical stimulation methods have used the highest possible currents and/or frequencies to attenuate action potentials of peripheral nociceptors and thus reduce the central perception of pain.

Such methods include transcutaneous electrical nerve stimulation (TENS), percutaneous stimulation (e.g., electroacupuncture) and surgically implanted devices such as peripheral nerve stimulators (PNS), spinal cord stimulators (SCS) and dorsal root ganglion (DRG) stimulators. All these electrical stimulation devices work in a similar way and use the same electrophysiological principle. Dynamic, pulsed bipolar electrical stimuli (1-70 V, 1-90 mA, 1-1200 Hz, pulse width of 0.2-250 ms) are used to overstimulate neurons to the point that they no longer generate action potentials, thereby interrupting afferent conduction in motor or neurological pain conditions. These electrical devices are widely used and clinically established, even though their clinical efficacy has not been clearly proven. The treatment is aimed only at pain suppression, and there is no clinical claim or evidence that these methods improve recovery or healing. Another class of electrical stimulation uses thermal and similar methods. These include electrochemical ablation (percutaneous thermocoagulation or electrolysis) to reduce anatomical pressure on a nerve, interrupt nociception and promote consecutive angiogenesis and tissue repair.

axomera and the axolotl

Electrophysiological phenomena, however, are not limited to these dynamic action potentials. The axolotl, for example, which is known for its ability to regrow injured limbs and organs, and even parts of the heart and brain, generates static electrical fields (EF) with a defined orientation and intensity during the regeneration phase.

Charged ions and proteins/peptides are found both in the extracellular matrix and intracellularly. Ion channels and ion transporters in the cell membrane regulate the flow of these charged molecules. In this way each tissue generates electric ion currents and electric fields (EFs) that have a defined orientation and intensity. These EFs in turn interact with charged ions and peptides through electrostatic forces, electrophoresis and electroosmosis. For example, inflammation of muscle tissue, which manifests as painful trigger points, is associated with locally increased concentrations of proinflammatory cytokines, H+ ions, and consequent acidosis, which in turn leads to increased electrical conductivity of the inflamed tissue.
Unterschiedliche Stromkurven während der Regenerationsphase beim Axolotl und beim Säugetier (Menschen).
Different current curves during the regeneration phase
in the axolotl and in mammals (humans).

electric fields on epithelial layers control wound healing

Electrical fields induced by cells and tissues include, for example, the transepithelial potential difference (TEP). In epithelial tissues, palisaded epithelial cells often generate a net influx of Na+ ions towards the parenchyma. In terms of their electrical properties, epithelial layers can be compared to multiple micro-batteries connected in parallel. Epithelial cells are connected to each other by so-called tight junctions, which have an electrically insulating effect. This maintains a potential difference between the inner parenchyma and the outer structures.

If injury to epithelial tissues destroys these tight junctions and also produces local edema, there is a local breakdown of the electrical resistance in the area of the wound and thus a short circuit of the TEP. Depending on the size and location of the wound, as well as the species and type of tissue injured, electric fields in the order of 140 mV/ mm are generated. A large number of new scientific studies have investigated the significance of these EFs for the control of cells. These biological EFs stimulate the migration of inflammatory cells, epithelial cells and fibroblasts. Depending on the orientation and intensity of the EF, fibroblasts migrate toward or away from the wound. This leads to opening or closing of the wound. Small EFs also stimulate and control the growth of spinal neurons, astrocytes, mesenchymal stem cells, monocytes and macrophages.

use of static electric fields in medicine

New clinical applications in the field of in vitro tissue engineering and to promote wound healing have been inspired by this recently acquired electrophysiological knowledge.

axomera - a transformational therapy method

With Axomera, this knowledge, which has only been known for a few years, is now being used for the first time for the treatment of neurological pain disorders and diseases of the musculoskeletal system. Comparable to the electrical fields measured during the regeneration phase in the axolotl (and in contrast to the TENS-like procedures described above), in Axomera therapy an undulating, unipolar current is generated by a microprocessor, which is placed precisely in the diseased or injured tissue with the help of fine electrical probes. The physiological electrical field of the tissue is imitated and increased in order to modulate local tissue inflammation and initiate regeneration of muscles, ligaments, tendons and nerves.

Das Axomera Feld stimuliert die Zellwanderung und fördert hierdurch die Heilung
The Axomera field stimulates cell migration and thereby promotes healing

Case study of the regeneration of injured thigh muscle

A 19-year-old professional soccer player suffered a stabbing pain in his right thigh during the second half of the game. The physician on the sidelines diagnosed a torn muscle, which was confirmed by MRI, and the prognosis was that the player would be out of play for at least three months due to the size of the injury. The player received five Axomera sessions over the next 10 days. After the second treatment, the pain subsided, and after the fourth treatment he was able to bear weight without pain.

Muskelfaserriss, MRI am Tag des Traumas
Muscle fibre tear, MRI on the day of the trauma
Training resumed after 11 days instead of 3 months
After the fifth treatment, the player wanted to return to sports-specific training. Due to the unexpectedly fast pain reduction, the attending physician ordered another MRI to be on the safe side, which clearly showed regeneration of the torn muscle. Thereupon the patient resumed training. Only three weeks after the trauma, he was able to play a complete 90-minute match with no discomfort.

Muskelfaserriss, MRI 11 Tage nach dem Trauma
Muscle fibre tear, MRI 11 days after trauma


  1. Nnoaham KE, Kumbang J. Transcutaneous electrical nerve stimulation (TENS) for chronic pain. Cochrane Database Syst Rev. 2008;(3):CD003222.
  2. Shamji MF, De Vos C, Sharan A. The Advancing Role of Neuromodulation for the Management of Chronic Treatment-Refractory Pain. Neurosurgery. 2017;80(3):S108-S113. doi:10.1093/neuros/nyw047.
  3. Petersen EA, Slavin K V. Peripheral nerve/field stimulation for chronic pain. Neurosurg Clin N Am. 2014;25(4):789-797. doi:10.1016/
  4. Zeng Z, Yan M, Dai Y, Qiu W, Deng S, Gu X. Percutaneous bipolar radiofrequency thermocoagulation for the treatment of lumbar disc herniation. J Clin Neurosci. 2016;30:39-43. doi:10.1016/j.jocn.2015.10.050.
  5. García Naranjo J, Barroso Rosa S, Loro Ferrer JF, Limiñana Cañal JM, Suarez Hernández E. A novel approach in the treatment of acute whiplash syndrome: Ultrasound-guided needle percutaneous electrolysis. A randomized controlled trial. Orthop Traumatol Surg Res. 2017;103(8):1229-1234. doi:10.1016/j.otsr.2017.09.012.
  6. McCaig CD, Song B, Rajnicek AM. Electrical dimensions in cell science. J Cell Sci. 2009;122(23):4267-4276. doi:10.1242/jcs.023564
  7. Shah JP, Danoff J V, Desai MJ, et al. Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points. Arch Phys Med Rehabil. 2008;89(1):16-23.
  8. Mccaig CD, Rajnicek AM, Song B, Zhao M. Controlling cell behavior electrically: current views and future potential. Physiol Rev. 2005;85(3):943-978.
  9. Electrical Stimulation Promotes Wound Healing by Enhancing Dermal Fibroblast Activity and Promoting Myofibroblast Transdifferentiation.
  10. Borgens RB, Vanable JW, Jaffe LF. Bioelectricity and regeneration. I. Initiation of frog limb regeneration by minute currents. J Exp Zool. 1977;200(3):403-416. doi:10.1002/jez.1402000310.
  11. Leppik LP, Froemel D, Slavici A, et al. Effects of electrical stimulation on rat limb regeneration, a new look at an old model. Sci Rep. 2015;5:18353. doi:10.1038/srep18353.
  12. Baer ML, Colello RJ. Endogenous bioelectric fields: A putative regulator of wound repair and regeneration in the central nervous system. Neural Regen Res. 2016;11(6):861-864. doi:10.4103/1673-5374.184446.
  13. Zhao M, Song B, Pu J, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature. 2006;442(7101):457-460.
  14. Borgens RB, Jaffe LF, Cohen MJ. Large and persistent electrical currents enter the transected lamprey spinal cord. Proc Natl Acad Sci U S A. 1980;77(2):1209-1213. doi:10.1073/pnas.77.2.1209.
  15. Baer ML, Henderson SC, Colello RJ. Elucidating the Role of Injury-Induced Electric Fields (EFs) in Regulating the Astrocytic Response to Injury in the Mammalian Central Nervous System. Hu W, ed. PLoS One. 2015;10(11):e0142740. doi:10.1371/journal.pone.0142740.
  16. Zhao Z, Watt C, Karystinou A, et al. Directed migration of human bone marrow mesenchymal stem cells in a physiological direct current electric field. Eur Cell Mater. 2011;22:344-358.
  17. Hoare JI, Rajnicek AM, Mccaig CD, Barker RN, Wilson HM. Electric fields are novel determinants of human macrophage functions. 2016;99(June):1-11. doi:10.1189/jlb.3A0815-390R.
  18. Electric Fields Stimulate Directional Migration of Synovial Mesenchymal Stem Cells Yayman G, MolsbergerA, Rajnicek AM, McCaig C
© 2021 axomera – inspiring medicine. all rights reserved.
Axomera is a novel treatment method developed on the basis of established methods. Although studies have been carried out on Axomera, like the majority of established medical treatments, it has not yet been fully validated according to the principles of evidence-based medicine. In particular, no randomized controlled trials or comprehensive meta-analyses have yet been carried out. The success of Axomera therapy cannot be guaranteed in every case. However, there are a large number of patient reports, case studies and testimonials on conditions that have been successfully treated with Axomera therapy. They may be found on this website and also on

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